The Giants roll into Fenway well under .500 at 52-75, while the Red Sox are chasing a wild card berth at 68-59, so this one's got real stakes for Boston even if San Francisco is playing spoiler. Vegas has the Sox as heavy favorites at -170 with an over/under of 7.5, meaning Boston's lineup is expected to feed off a shaky Giants pitching staff all night.

Keep an eye on the bullpen usage late — if the Sox starter can't work deep into the game, their manager might have to go to the pen earlier than he'd like against a scrappy lineup. Bold prediction: Boston's heart of the order gets to San Francisco's starter early and this one turns into a laugher by the fifth inning.